IMTEC-PR3-ANCA is an indirect solid-phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against proteinase 3 in human serum. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of autoimmune vasculitides such as Wegeners granulomatosis.

Proteinase 3 (PR3) is the main target of cytoplasmic anti-neutrophil cytoplasm antibodies (cANCA). In contrast to that, perinuclear ANCA (pANCA) mainly react with myeloperoxidase (MPO). Anti-Neutrophil Cytoplasm Antibodies (cANCA) are closely related to Wegener's granulomatosis classically causing severe glomerulonephritis. Repeated examination for ANCA is therefore of value for monitoring of disease activity and effect of treatment.

Code ITC82020  96Tests