IMTEC-Vasculitis-LIA is an indirect membrane based enzyme immunoassay (LIA) for the qualitative measurement of IgG class antibodies against PR3, MPO and GBM in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of systemic vasculitis, i.e. Wegener’s granulomatosis, and the Goodpasture syndrome. Proteinase 3 (PR3) is the main target of cytoplasmic anti-neutrophil cytoplasm antibodies (cANCA).

In contrast to that, perinuclear ANCA (pANCA) mainly react with myeloperoxidase (MPO). cANCA are closely related to Wegener's granulomatosis classically causing severe glomerulonephritis. Repeated examination for cANCA is therefore of value for monitoring of disease activity and effect of treatment.

Code ITC82040  24Tests