MYOSITIS-LIA PL is an indirect membrane based enzyme immuneassay for the qualitative measurement of IgG class antibodies against Jo1, Mi2, PM-Scl, U1-snRNP, Ku, PL-7 and PL-12 in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of poly- and dermatomyositis and myositis-associated overlap syndromes.

Antibodies to aminoacyl-t-RNA-synthesases anti-Jo-1, anti-PL-7 and antiPL-12 indicate the anti-synthetase syndrome (ASS). The clinical manifestations of anti-synthetase syndrome are often myositis associated with interstitial lung disease. 60-80% of ASS patients are positive for one of the aminoacyl-t-RNA-synthesase antibodies. In addition clinical symptoms like arthritis, Raynaud-phenomenon, fever and “mechanic’s hands” can be detected.

Code ITC60201  24Tests