IMTEC-SS-A/Ro-Antibodies is an indirect solid-phase enzyme immunoassay (ELISA) for quantitative and qualitative measurement of IgG class autoantibodies against SS-A in human serum. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Sjögren’s syndrome.

Autoantibodies directed to Ro52 and Ro60 are highly specific for Sjögren's syndrome (SS) and for systemic lupus erythematosus (SLE) respectively. In over 60% of primary SS (pSS) anti-Ro52-antibodies are occurring isolated (only 5% in SLE). An isolated occurrence of anti-Ro60 antibodies was observed in 11% of SLE but none in pSS. If anti-Ro60 antibodies are positive but anti-SS/B-La antibodies negative, a development of nephritis is significantly more likely than in other patients with SLE. Anti-SS-A/Ro antibodies have been detected in nearly 100% of newborns with neonatal lupus erythematosus (NLE). There is a strong correlation between positive test results for anti-SS-A/Ro antibodies and the occurrence of a congenital heart block.

Code ITC70026  96Tests